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FLASH GENE

Symbol

RGS12

contributors: npt/ - updated : 03-03-2007

HGNC name	regulator of G-protein signaling 12
HGNC id	9994

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	125.77 kb     18 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 2 - - 4870 - 1376 - Snow, Jin RGS12TS or variant 1 - splicing 5480 - 1447 widely Snow, Chatterjee, Jin alternative 3'end with a putative C terminal PDZ domain RGS12L - splicing 3530 - - - Snow, Chatterjee lacking the PDZ domain RGS12S - splicing 2600 - 789 - Snow, Chatterjee lacking the PDZ domain with the 3'end RGS12B or variant 3 - - 2900 - 799 . highly in brain and lung . lowly in testis, heart, spleen Chatterjee, Jin

EXPRESSION

Type	ubiquitous

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       highly Digestive esophagus       highly Nervous nerve cranial nerve     highly Reproductive male system prostate       Urinary kidney         Visual eye       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Lymphoid

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a N terminal PDZ (PSD-95/Dlg/ZO-1) domain
	a RGS domain (120AA) with three conserved motifs GH1, GH2, GH3
	a C terminal coiled-coil domain
	a PID domain
	a GOLOCO domain
	two RBD(ras-binding) domains

HOMOLOGY

interspecies	homolog to C.elegans EGL-10
	homolog to yeast SST2

Homologene

FAMILY

CATEGORY

regulatory , receptor membrane G

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus

basic FUNCTION	may function as a guanosine triphosphatase (GTPase)-activating protein as well as a transcriptional repressor
	negative regulator of G protein signaling 12, functioning as GTPase-activating protein for G protein alpha i and q subunits

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

through its PTB domain with the tyrgine-phosphorylated N-type calcium channel

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS