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FLASH GENE
Symbol F13B contributors: - updated : 19-12-2005
HGNC name coagulation factor XIII, B polypeptide
HGNC id 3534
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • ten short consensus repeats, sushi structure (see SRCP1)
    • mono polymer homomer , tetramer
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY enzyme , immunity/defense
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • acting as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS coagulation/hemostasis
    PATHWAY
    metabolism
    signaling
    a component
  • composed of 2 A subunits and 2 B subunits, the A subunits having catalytic function, and the B subunits do not have enzymatic activity and may serve as a plasma carrier molecules
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) F13B
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS