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FLASH GENE
Symbol F13B contributors: - updated : 19-12-2005
HGNC name coagulation factor XIII, B polypeptide
HGNC id 3534
Corresponding disease
F13B fibrin-stabilizing factor deficiency, type I
Location 1q31-q32.1      Physical location : 197.008.320 - 197.036.397
EC.number 2.3.2.13
DNA
TYPE functioning gene
STRUCTURE 28.00 kb     12 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked Y status confirmed
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • ten short consensus repeats, sushi structure (see SRCP1)
    • mono polymer homomer , tetramer
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY enzyme , immunity/defense
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • acting as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS coagulation/hemostasis
    PATHWAY
    metabolism
    signaling
    a component
  • composed of 2 A subunits and 2 B subunits, the A subunits having catalytic function, and the B subunits do not have enzymatic activity and may serve as a plasma carrier molecules
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) F13B
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS