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FLASH GENE
Symbol UBE2G2 contributors: mct/pgu - updated : 21-10-2011
HGNC name ubiquitin-conjugating enzyme E2G 2 (UBC7 homolog, yeast)
HGNC id 12483
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a conserved UBC domain of 150 AA harboring the cysteine residue required for enzyme-ubiquitin thioester formation
  • extra loop region interacting with the RING domain or its neighbouring region and may be involved in the binding specificity and stability
    • secondary structure alpha/beta protein with four alpha-helices and a four-stranded antiparallel beta-sheet
    HOMOLOGY
    interspecies homolog to yeast UBC7
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,cytosolic
    text cytosolic E2 ubiquitin ligase
    basic FUNCTION
  • involved in protein degradation, including a process known as endoplasmic reticulum-associated degradation
  • UBE2G1 and UBE2G2 cooperate with IL17RB to polyubiquitylate and degrade CDT1 postradiation, an activity that is critical for preventing origin licensing in DNA-damaged cells
  • acts as the E2-conjugating enzyme for AMFR, another E3 ubiquitin ligase that specializes in the ubiquitylation of dislocated ER proteins
    • CELLULAR PROCESS cell cycle
    protein, degradation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interactions between TRIM9 and UBE2G2
  • AUP1 binds UBE2G2 and this interaction is dependent on the C terminus of AUP1 that constitutes a G2BR domain
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS