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FLASH GENE

Symbol

UBE2G2

contributors: mct/pgu - updated : 21-10-2011

HGNC name	ubiquitin-conjugating enzyme E2G 2 (UBC7 homolog, yeast)
HGNC id	12483

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
SPECIAL FEATURE	head to head
STRUCTURE	32.00 kb     6 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed V1 - - 2919 2.9 165 - 2006 16582478 V2 - - 3034 - 137 ubiquitous 2006 16582478

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Lymphoid/Immune thymus       highly Visual eye       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective bone     highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a conserved UBC domain of 150 AA harboring the cysteine residue required for enzyme-ubiquitin thioester formation
	extra loop region interacting with the RING domain or its neighbouring region and may be involved in the binding specificity and stability

secondary structure

alpha/beta protein with four alpha-helices and a four-stranded antiparallel beta-sheet

HOMOLOGY

interspecies

homolog to yeast UBC7

Homologene

FAMILY

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	extracellular
	intracellular
	intracellular,cytoplasm,cytosolic
text	cytosolic E2 ubiquitin ligase

basic FUNCTION	involved in protein degradation, including a process known as endoplasmic reticulum-associated degradation
	UBE2G1 and UBE2G2 cooperate with IL17RB to polyubiquitylate and degrade CDT1 postradiation, an activity that is critical for preventing origin licensing in DNA-damaged cells
	acts as the E2-conjugating enzyme for AMFR, another E3 ubiquitin ligase that specializes in the ubiquitylation of dislocated ER proteins

CELLULAR PROCESS	cell cycle
	protein, degradation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	interactions between TRIM9 and UBE2G2
	AUP1 binds UBE2G2 and this interaction is dependent on the C terminus of AUP1 that constitutes a G2BR domain

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS