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FLASH GENE

Symbol

SLIT3

contributors: mct/npt - updated : 28-05-2010

HGNC name	slit homolog 3 (Drosophila)
HGNC id	11087

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Endocrine pancreas       predominantly Homo sapiens   thyroid         Nervous brain hindbrain cerebellum     Urinary kidney       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial secretory glandular endocrine

cells

System Cell Pubmed Species Stage Rna symbol Endocrine islet cell (alpha,beta...) Homo sapiens Urinary epithelial cell

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

embryo

Text	co-expressed in embryonic stem (ES) cells with embryoid body formation (Katoh 2005)

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	an N-terminal mitochondrial localization signal that can direct a reporter green fluorescent protein to the mitochondria
	secretory protein with four leucine rich repeats (LRR)
	two calcium binding type
	nine EGF domains
	Laminin G (LamG) domain, and SLITCCR domain (Katoh 2005)
	seven EGF-like motifs

HOMOLOGY

interspecies	homolog to SLIT Drosophila 3
	homolog to murine Slit3

Homologene

FAMILY

laminin G family

CATEGORY

regulatory , secretory

SUBCELLULAR LOCALIZATION	extracellular
	intracellular
	intracellular,cytoplasm,organelle,mitochondria
text	predominantly localized within the mitochondria (Little 2001)
	maximal in the late-luteal phase and significantly reduced after luteal rescue (Dickinson 2008)

basic FUNCTION	chemorepellent, involved in histogenesis of central nervous system and endocrine systems
	has potentially unique functions not shared by other Slit proteins (Little 2001)
	involved in the formation of the diaphragm and kidney during embryogenesis (Tanno 2007)
	functions as an intracellular signaling molecule for cell motility as part of the LPS-induced signaling cascade (Tanno 2007)
	axon-guidance-pathway molecules are involved in connectivity and repair throughout life (beyond guiding brain wiring during fetal development) (Lin 2009)
	dispensable for neural development but required for non-neuron-related developmental processes, such as the genesis of the diaphragm and kidney (Zhang 2009)
	repulsive axon guidance molecule which is a novel and potent angiogenic factor and functions to promote angiogenesis in coordinating organogenesis during embryonic development (Zhang 2009)
	role during the angiogenic process that relies on the directional migration not only of endothelial cells but also of pericytes
	SLIT2 may act in an autocrine manner on beta cells, whereas SLIT1 and SLIT3 may play both autocrine and paracrine roles

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

development

text	neurogenesis
	maintenance of dorsal position by preventing axonal growth into the ventral region
	prevention of axonal extension toward and across the midline
	channneling of axons toward particular region

PATHWAY

metabolism

signaling

SLIT signaling depletes ER Ca2+ and protects beta cells from ER stress

a component

INTERACTION

DNA

RNA

small molecule

protein	ligand to GPC1(glypican 1)
	ligand for ROBO proteins increasing SrGAP1-ROBO1 interaction
	inactivating CDC42

cell & other

REGULATION

induced by

lipopolysaccharide (LPS)-stimulation in macrophages (Tanno 2007)

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral       loss of function in human cancers and may regulate apoptosis and metastasis (Dickinson 2008)

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS