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FLASH GENE
Symbol FAT2 contributors: mct - updated : 11-04-2022
HGNC name FAT tumor suppressor homolog 2 (Drosophila)
HGNC id 3596
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a 18 aa signal peptide
  • thirty two cadherin motifs
  • a laminin G-like domain
  • two EGF-like motifs
    • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to rattus Fat2 (81.8 pc)
    homolog to murine Fat2 (82 pc)
    Homologene
    FAMILY
  • cadherin superfamily
    • CATEGORY adhesion
    SUBCELLULAR LOCALIZATION     plasma membrane,junction,adherens
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    text
  • single-pass type I membrane protein
  • localized at immature adherens junctions
    • basic FUNCTION
  • controlling cell proliferation
  • playing an important role in cerebellum development
  • acts through the WAVE regulatory complex to drive collective cell migration during tissue rotation
  • may function as a key molecule that governs not only planar cell polarity (PCP), but also NF2-HIPPO signaling in arachnoid cells
  • FAT2 and the receptor tyrosine phosphatase PTPRF function in a planar signaling system that coordinates leading and trailing edge dynamics between neighboring cells
    • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS development
    text
  • cerebellum development
    • PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Ca2+
    • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) SCA45
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    significantly associated with lymph node and distant metastases, and poor prognosis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
  • FAT2 and DCHS2 are candidates underlying pituitary gland developmental defects such as ectopic pituitary gland and/or pituitary stalk interruption
    • Marker
    Therapy target
    ANIMAL & CELL MODELS