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FLASH GENE
Symbol FAT2 contributors: KTN/npt - updated : 03/12/2008
HGNC name FAT tumor suppressor homolog 2 (Drosophila)
HGNC id 3596
Location 5q33.1      Physical location : 150.883.653 - 150.948.505
Synonym name
  • multiple epidermal growth factor-like motif 1
  • protocadherin FAT2
  • cadherin family member 8
  • Synonym symbol(s) MEGF1, CDHF8, HFAT2, KIAA0811
    DNA
    TYPE functioning gene
    STRUCTURE 64.85 kb     23 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Physical map
    CSF1R 5q31.3 colony stimulating factor 1 receptor, formerly McDonough feline sarcoma viral (v-fms) oncogene homolog RPL7P 5q33.3 ribosomal protein L7 pseudogene PDGFRB 5q31.3 platelet-derived growth factor receptor, beta polypeptide CDX1 5q31.3 caudal type homeo box transcription factor 1 SLC6A7 5q31-q32 solute carrier family 6 (neurotransmitter transporter, L-proline), member 7 CAMK2A 5q33.2 calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha LOC340075 5q33.1 similar to RIKEN cDNA 9330196J05 TCOF1 5q32-q33.1 Treacher Collins-Franceschetti syndrome 1 CD74 5q31.3 CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) RPS14 5q32 ribosomal protein S14 NDST1 5q31.3-q32 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1 SYNPO 5q33.1 synaptopodin MYOZ3 5q33.1 myozenin 3 FLJ10290 5q33.1 hypothetical protein FLJ10290 DCTN4 5q31-q32 dynactin 4 (p62) NID67 5q33.1 putative small membrane protein NID67 LRG47 5q33.1 LRG-47-like protein ZNF300 21 zinc finger protein 300 GPX3 5q23 glutathione peroxidase 3 (plasma) TNIP1 5q32-q33.1 TNFAIP3 interacting protein 1 ANXA6 5q32 annexin A6 DKFZP434C171 5q33.1 DKFZP434C171 protein GM2A 5q32 GM2 ganglioside activator protein SLC36A3 5q33.1 solute carrier family 36 (proton/amino acid symporter), member 3 SLC36A2 5q33.1 solute carrier family 36 (proton/amino acid symporter), member 2 LOC391840 5 similar to Thyroid hormone receptor-associated protein complex 240 kDa component (Trap240) (Activator-recruited cofactor 250 kDa component) (ARC250) LOC391841 5 similar to hypothetical protein DKFZp761H0421 SLC36A1 5q33.1 solute carrier family 36 (proton/amino acid symporter), member 1 FAT2 5q31-q32 FAT tumor suppressor homolog 2 (Drosophila) SPARC 5q32 secreted protein, acidic, cysteine-rich (osteonectin) ATOX1 5q32-q33 ATX1 antioxidant protein 1 homolog (yeast) LOC389338 5 LOC389338 G3BP 5q33.3 LOC389338 GLRA1 5q32 glycine receptor, alpha 1 (startle disease/hyperekplexia, stiff man syndrome) GLULL1 5q33 glutamate-ammonia ligase (glutamine synthase)-like 1 NMU2R 5q33.2 neuromedin U receptor 2
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    23 - 14565 479.2 4349 - -
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus   moderately
     mouth   highly
    Endocrineneuroendocrinepituitary  moderately
     parathyroid   predominantly
    Nervousbrain    
    Reproductivefemale systemovary  moderately
    Respiratoryrespiratory tractlarynx  moderately
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a 18 aa signal peptide
  • thirty two cadherin motifs
  • a laminin G-like domain
  • two EGF-like motifs
  • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to dog FAT2 (88.5 pc)
    homolog to chimpanzee FAT2 (99.3 pc)
    homolog to cow FAT2 (87 pc)
    homolog to rattus Fat2 (81.8 pc)
    homolog to murine Fat2 (82 pc)
    Homologene
    FAMILY
  • cadherin superfamily
  • CATEGORY adhesion
    SUBCELLULAR LOCALIZATION     plasma membrane,junction,adherens
    text
  • single-pass type I membrane protein
  • localized at immature adherens junctions
  • basic FUNCTION
  • controlling cell proliferation
  • playing an important role in cerebellum development
  • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS development
    text
  • cerebellum development
  • PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Ca2+
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS