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FLASH GENE
Symbol MEGF9 contributors: npt/mct - updated : 03/12/2008
HGNC name multiple EGF-like-domains 9
HGNC id 3234
Location 9q32-q33.3      Physical location : 123.363.196 - 123.476.765
Synonym name
  • multiple epidermal growth factor-like motif 9
  • EGF-like-domain, multiple 5
  • Synonym symbol(s) EGFL5, KIAA0818
    DNA
    TYPE functioning gene
    STRUCTURE 113.52 kb     8 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 6297 - 639 - Humphray (2004)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen   highly
    Cardiovascularheart   highly
    Nervousbrainhindbraincerebellum predominantly
    Respiratorylung   highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousglia
    Nervousneuron
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text in the developing CNS (central nervous system) and PNS (peripheral nervous system
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an N-terminal region with several potential O-glycosylation sites followed by five EGF-like domains, which are highly homologous with the short arms of laminins
  • membrane anchored protein with an EGF-like motif
  • three laminin type EGF-like motifs
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY signaling , receptor
    SUBCELLULAR LOCALIZATION
    basic FUNCTION putative receptor, expressed in neuronal and non-neuronal tissues, that is regulated during development and could function as a guidance or signalling molecule
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS