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FLASH GENE
Symbol MEGF8 contributors: mct - updated : 05-12-2012
HGNC name multiple EGF-like-domains 8
HGNC id 3233
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • membrane anchored protein with a laminin type EGF-like
  • five EGF-like motifs
    • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY motor/contractile
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • essential regulator of left-right patterning (
  • possible involvement in astrocytic engulfment
  • function for MEGF8 in intracellular trafficking could account for both the presence of the predicted transmembrane domain and the phenotypic similarity in the consequences of MEGF8 and RAB23 mutations
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS