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FLASH GENE

Symbol

MEGF8

contributors: mct - updated : 05-12-2012

HGNC name	multiple EGF-like-domains 8
HGNC id	3233

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Endocrine pancreas         Nervous brain         Reproductive male system prostate       Respiratory lung         Urinary kidney

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	membrane anchored protein with a laminin type EGF-like
	five EGF-like motifs

HOMOLOGY

Homologene

FAMILY

CATEGORY

motor/contractile

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION	essential regulator of left-right patterning (
	possible involvement in astrocytic engulfment
	function for MEGF8 in intracellular trafficking could account for both the presence of the predicted transmembrane domain and the phenotypic similarity in the consequences of MEGF8 and RAB23 mutations

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS