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FLASH GENE
Symbol MEGF6 contributors: mct - updated : 22-03-2020
HGNC name multiple EGF-like-domains 6
HGNC id 3232
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • three calcium binding type EGF-like motifs
  • 30 EGF-like domains containing two additional cysteine residues
    • HOMOLOGY
    Homologene
    FAMILY MEGF (multiple EGF-like domains) protein family
    CATEGORY secretory , protooncogene
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • may serve as an oncogene to promote cell proliferation and inhibit apoptosis
  • can also accelerate cell migration via TGFB1/SMAD signaling-mediated EMT
  • is dispensable for embryonic development
  • MEGF6-expressing cells contribute to the periotic mesenchyme and its derivatives, skin epidermis, certain cells in brain and ribs
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to SAPHO syndrome
    Variant & Polymorphism other
  • association between CNV in MEGF6, and SAPHO syndrome
    • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS