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FLASH GENE

Symbol

CELSR2

contributors: mct/shn/pgu - updated : 19-09-2010

HGNC name	cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila)
HGNC id	3231

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

	Knocking down rat Celsr2 results in prominent simplification of dendritic arbors of cortical pyramidal neurons and Purkinje neurons
	Celsr2 deficient mice fail to develop the ependymal cilia in the cerebral ventricles leading to defective cerebrospinal fluid dynamics and hydrocephalus
	Celsr2/Celsr3 double mutant mice display markedly impairment of ependyma and ciliogenesis leading to lethal hydrocephalus