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FLASH GENE
Symbol TPTE contributors: npt/ - updated : 06-09-2007
HGNC name transmembrane phosphatase with tensin homology
HGNC id 12023
Location 21p11.1      Physical location : 10.906.742 - 10.990.920
Synonym name
  • tensin, putative protein-hydrosyne phosphatase
  • PTEN-related tyrosine phosphatase
  • tumor antigen BJ-HCC-5
  • cancer/testis antigen 44
  • Synonym symbol(s) PTEN2, CT44
    EC.number 3.1.3.48
    DNA
    TYPE functioning gene
    STRUCTURE 84.18 kb     24 Exon(s)    4 Copie(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Physical map
    TPTE 21p11 transmembrane phosphatase with tensin homology HCP41 21p11 cytochrome c, somatic pseudogene BAGE4  B melanoma antigen family, member 4 BAGE 21p11.1 B melanoma antigen EIF3S5P 21p11.2 eukaryotic translation initiation factor 3, subunit 5 epsilon, 47kDa pseudogene C21orf99 21q22.1 chromosome 21 open reading frame 99 VN1R8P 21q11 vomeronasal 1 receptor 8 pseudogene LOC391264 21 similar to Sorting nexin 19 ANKRD21 21q11.2 ankyrin repeat domain 21 LOC391265 21 similar to cDNA sequence BC021523 LOC388810 21 hypothetical gene supported by AL834140
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    23 - 2145 62.3 533 - -
    22 - 2085 60.1 513 - -
    24 - 2199 64.2 551 - -
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivemale systemtestis   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • four transmembrane segments (2TM)
  • a C terminal tyrosine phosphatase motif
  • an extensive homology to chicken tensin
  • HOMOLOGY
    interspecies ortholog to murine Tpte
    intraspecies homolog to TPTEL1,TPTEL2,TPTEL4,TPTELY
    homolog to tensin
    Homologene
    FAMILY
  • non receptor class of the protein-tyrosine phosphatase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,Golgi
    basic FUNCTION
  • transmembrane phosphatase
  • putatively involved in linking the cell membrane to cytoskeleton
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS