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FLASH GENE

Symbol

TBX15

contributors: mct/npt - updated : 29-03-2013

HGNC name	T-box 15
HGNC id	11594

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

PVSD

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   in preadipocytes, such as occurs in visceral fat of lean individuals, reduces adipocyte differentiation capacity and impairs adipocyte triglyceride accumulation

Susceptibility

Variant & Polymorphism

Candidate gene	maybe a candidate gene for acromegaloid facial appearance syndrome
Marker
Therapy target
	System Type Disorder Pubmed obesity     targeting the mechanism by which TBX15 controls mitochondrial mass and activity in preadipocytes, could provide new strategies for the prevention of visceral fat accumulation and potentially lead to therapies for obesity-linked insulin-resistant states

ANIMAL & CELL MODELS