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FLASH GENE
Symbol TBX15 contributors: mct/npt - updated : 29-03-2013
HGNC name T-box 15
HGNC id 11594
Corresponding disease
PVSD pelviscapular dysplasia
Location 1p13-p11.1      Physical location : 119.425.665 - 119.532.179
Synonym name
  • T-box 14
  • T-box transcription factor TBX15
  • Synonym symbol(s) TBX14
    DNA
    TYPE functioning gene
    STRUCTURE 106.50 kb     8 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 3513 - 496 - 2005 15652702
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Hearing/Equilibriumear    
    Nervousnerve    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone   
    Muscularstriatumskeletal  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    not specificadipocyte Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo
    Text craniofacial region and developing limbs
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a large N terminal DNA binding domain (T-box)
  • HOMOLOGY
    interspecies homolog to murine T-box gene Tbx15 (T,brachyury)
    Homologene
    FAMILY
  • T-box family
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • involved in the regulation of developmental processes
  • may have played a role in patterning somites in the last common ancestor of all chordates
  • plays an important role in the development of the skeleton of the limb, vertebral column and head by controling the number of mesenchymal precursor cells and chondrocytes
  • required for the condensation of mesenchymal precursor cells in early development of the skeleton
  • mainly acting as a gene repressor
  • might be involved in the pathophysiology of placental diseases
  • important role in controlling depot-specific adipocyte development and function
  • potential role in the depot-specific control of adipose tissue development and function
  • may regulate intraabdominal adipose tissue development and fat accumulation and thus play a role in the development of central obesity and metabolic syndrome
  • TBX2, TBX3, TBX4, TBX5 and three members of TBX1 (TBX1, TBX15, TBX18), Brachyury (T) and Eomes (TBR2) are expressed in the developing limb
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding through T-box
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) PVSD
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in preadipocytes, such as occurs in visceral fat of lean individuals, reduces adipocyte differentiation capacity and impairs adipocyte triglyceride accumulation
    Susceptibility
    Variant & Polymorphism
    Candidate gene maybe a candidate gene for acromegaloid facial appearance syndrome
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    obesity  
    targeting the mechanism by which TBX15 controls mitochondrial mass and activity in preadipocytes, could provide new strategies for the prevention of visceral fat accumulation and potentially lead to therapies for obesity-linked insulin-resistant states
    ANIMAL & CELL MODELS