SUBCELLULAR LOCALIZATION
| plasma membrane
|
| intracellular
|
|
| intracellular,cytoplasm,organelle,membrane
|
|
| intracellular,cytoplasm,organelle,endoplasmic reticulum
|
|
| intracellular,cytoplasm,organelle,Golgi
|
|
| intracellular,cytoplasm,organelle,lysosome
|
| basic FUNCTION
| placental cysteine proteinase, with putative exopeptidase activity |
|
may be involved in tumorigenesis |
|
has a restricted catalytic specificity |
|
extracellular function of cathepsin Z may include binding to integrins thereby modulating the attachment of migrating cells to extracellular matrix components  |
|
with BLMH, are both cysteine proteases of a papain-like structure, and mediate N-terminal proteolysis and toxicity of mutant huntingtin |
|
cysteine carboxypeptidase, that is involved in the regulation of T cell migration by interaction with ITGAL, ITGB2 |
|
potential role of cathepsin Z in bypassing cellular senescence |
|
CTSL, CTSZ, account for the lysosome's capacity to digest polyQ sequences, and are important in defending against the accumulation and toxicity of polyQ proteins |
|
several of the tumor-promoting functions of CTSZ were not dependent on its described catalytic activity but instead were mediated via the Arg-Gly-Asp (RGD) motif in the enzyme prodomain, which regulated interactions with integrins and the extracellular matrix |
|
role for CTSZ in the anti-tumor immune response |
|
predominantly supplied by tumor-associated macrophages, and is the compensatory protease that regulates the acquired tumor-promoting functions of lesions deficient in both CTSB and CTSS |
