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FLASH GENE

Symbol

SYMPK

contributors: mct/npt - updated : 19-01-2016

HGNC name	symplekin
HGNC id	22935

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   may be an early step in the transformation of hepatocytes, whereas alteration of the expression of adherens junctions and desmosomes may indicate more serious changes (Cao 2007) tumoral     --over   nuclear overexpression promotes tumorigenesis in the colon and the regulation of CLDN2 expression is instrumental in this effect (Buchert 2010) tumoral     --over   in lung and colon cancer cells

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer     therapeutic regimens that combine antimitotics with polyadenylation inhibitors may have an enhanced effectiveness for cytotoxicity in tumor cells while decreasing adverse events in normal tissues

ANIMAL & CELL MODELS