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FLASH GENE
Symbol F7 contributors: mct - updated : 09-09-2014
HGNC name coagulation factor VII (serum prothrombin conversion accelerator)
HGNC id 3544
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminus GLA domain followed by two cysteine-rich domains, highly homologous to EGF,
  • a C terminal catalytic (serine protease) domain
    • conjugated GlycoP
    mono polymer heteromer , dimer
    isoforms Precursor zymogen
    HOMOLOGY
    interspecies homolog to murine F7
    Homologene
    FAMILY peptidase family S1
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
    text plasma specific
    basic FUNCTION
  • coagulation factor VII, vitamin K-dependent, initiating the extrinsic pathway of blood coagulation
  • F7 and PROC are phosphatidic acid-binding proteins
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS coagulation/hemostasis
    PATHWAY
    metabolism
    signaling
    extrinsic pathway of blood coagulation
    a component
  • complexing with cofactor F3 or tissue factor
  • heterodimer of a light chain and a heavy chain linked by a disulfide bond
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • activating FIX, FX
  • binds to the endothelial cell protein C receptor (PROCR) on the vascular endothelium and F7 binding to PROCR on the endothelium facilitates the transport of F7 from circulation to extravascular tissues
    • cell & other
    REGULATION
    Other the active form being generated by the cleavage of Arg152-Ile153 peptide bond by FIXa,Fxa,FXIIa,FII,leading to two chains heavy (catalytic),light,held together by a disulfide bond
    ASSOCIATED DISORDERS
    corresponding disease(s) F7
    related resource Factor VII Mutation Database
    Susceptibility to myocardial infarction
    Variant & Polymorphism some F7 genotypes maybe a protective factor
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS