Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Orphanet Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol F7 contributors: mct - updated : 09-09-2014
HGNC name coagulation factor VII (serum prothrombin conversion accelerator)
HGNC id 3544
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoietic    
cell lineage
cell lines
fluid/secretion plasma
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminus GLA domain followed by two cysteine-rich domains, highly homologous to EGF,
  • a C terminal catalytic (serine protease) domain
    • conjugated GlycoP
    mono polymer heteromer , dimer
    isoforms Precursor zymogen
    HOMOLOGY
    interspecies homolog to murine F7
    Homologene
    FAMILY peptidase family S1
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
    text plasma specific
    basic FUNCTION
  • coagulation factor VII, vitamin K-dependent, initiating the extrinsic pathway of blood coagulation
  • F7 and PROC are phosphatidic acid-binding proteins
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS coagulation/hemostasis
    PATHWAY
    metabolism
    signaling
    extrinsic pathway of blood coagulation
    a component
  • complexing with cofactor F3 or tissue factor
  • heterodimer of a light chain and a heavy chain linked by a disulfide bond
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • activating FIX, FX
  • binds to the endothelial cell protein C receptor (PROCR) on the vascular endothelium and F7 binding to PROCR on the endothelium facilitates the transport of F7 from circulation to extravascular tissues
    • cell & other
    REGULATION
    Other the active form being generated by the cleavage of Arg152-Ile153 peptide bond by FIXa,Fxa,FXIIa,FII,leading to two chains heavy (catalytic),light,held together by a disulfide bond
    ASSOCIATED DISORDERS
    corresponding disease(s) F7
    related resource Factor VII Mutation Database
    Susceptibility to myocardial infarction
    Variant & Polymorphism some F7 genotypes maybe a protective factor
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS