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FLASH GENE

Symbol

F7

contributors: mct - updated : 09-09-2014

HGNC name	coagulation factor VII (serum prothrombin conversion accelerator)
HGNC id	3544

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	14.00 kb     9 Exon(s)

10 Kb 5' upstream gene genomic sequence study

regulatory sequence	Promoter
	Binding site   HRE
motif	repetitive sequence
text structure	oestrogene responsive element
	5' flanking region, the hepatic nuclear factor 4 binding region (-77 to -47) and the nuclear hormone response region (-237 to -200)

MAPPING

cloned

Y

linked

N

status

confirmed

regionally located

2.8 kb upstream F10

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 - - 2478 51 466 - Hagen variant 2 - splicing 2412 - 414 - Hagen isoform a variant 2 - splicing 2462 - 466 - Hagen alternative exon 1b isoform a variant 1 - - -

EXPRESSION

Type	restricted

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic

cell lineage
cell lines
fluid/secretion	plasma

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	N terminus GLA domain followed by two cysteine-rich domains, highly homologous to EGF,
	a C terminal catalytic (serine protease) domain

conjugated

GlycoP

mono polymer

heteromer , dimer

isoforms

Precursor

zymogen

HOMOLOGY

interspecies

homolog to murine F7

Homologene

FAMILY

peptidase family S1

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	extracellular
text	plasma specific

basic FUNCTION	coagulation factor VII, vitamin K-dependent, initiating the extrinsic pathway of blood coagulation
	F7 and PROC are phosphatidic acid-binding proteins

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

coagulation/hemostasis

PATHWAY

metabolism

signaling

extrinsic pathway of blood coagulation

a component	complexing with cofactor F3 or tissue factor
	heterodimer of a light chain and a heavy chain linked by a disulfide bond

INTERACTION

DNA

RNA

small molecule

protein	activating FIX, FX
	binds to the endothelial cell protein C receptor (PROCR) on the vascular endothelium and F7 binding to PROCR on the endothelium facilitates the transport of F7 from circulation to extravascular tissues

cell & other

REGULATION

Other

the active form being generated by the cleavage of Arg152-Ile153 peptide bond by FIXa,Fxa,FXIIa,FII,leading to two chains heavy (catalytic),light,held together by a disulfide bond

ASSOCIATED DISORDERS

corresponding disease(s)

F7

related resource

Factor VII Mutation Database

Susceptibility

to myocardial infarction

Variant & Polymorphism	some F7 genotypes maybe a protective factor

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS