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FLASH GENE
Symbol SNN contributors: mct - updated : 15-03-2004
HGNC name stannin
HGNC id 11149
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a single transmembrane domain (AAs 10-33),
  • a 28-AA linker region from residues 34-60 that contains a conserved CXC metal binding motif and a putative 14-3-3xi binding region,
  • a cytoplasmic helix (AA 61-79), which is partially embedded into the membrane
    • HOMOLOGY
    interspecies homolog to murine Snn
    homolog to C.elegans f28f8.3
    Homologene
    FAMILY
    CATEGORY chaperone/stress
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,organelle,membrane
    basic FUNCTION
  • involved in the toxic effect of organotins
  • having a possible role in several key signaling systems, including activation of the p38-ERK cascade, TP53-dependent pathways, and 14-3-3xi protein-mediated processes
  • constitutes an important sensor of mitochondrial damage, and plays a key role in the mediation of cross-talk between mitochondrial and nuclear compartments in specific cell types
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS