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FLASH GENE

Symbol

SNN

contributors: mct - updated : 15-03-2004

HGNC name	stannin
HGNC id	11149

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	8.00 kb     2 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 2 - 3307 - 88 - Mehrle (2006)

EXPRESSION

Type

widely

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol blood / hematopoietic spleen       highly Digestive salivary gland       highly Nervous brain       highly Urinary kidney

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Lymphoid

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a single transmembrane domain (AAs 10-33),
	a 28-AA linker region from residues 34-60 that contains a conserved CXC metal binding motif and a putative 14-3-3xi binding region,
	a cytoplasmic helix (AA 61-79), which is partially embedded into the membrane

HOMOLOGY

interspecies	homolog to murine Snn
	homolog to C.elegans f28f8.3

Homologene

FAMILY

CATEGORY

chaperone/stress

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,organelle,mitochondria
	intracellular,cytoplasm,organelle,membrane

basic FUNCTION	involved in the toxic effect of organotins
	having a possible role in several key signaling systems, including activation of the p38-ERK cascade, TP53-dependent pathways, and 14-3-3xi protein-mediated processes
	constitutes an important sensor of mitochondrial damage, and plays a key role in the mediation of cross-talk between mitochondrial and nuclear compartments in specific cell types

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS