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Symbol CDC20 contributors: mct/pgu - updated : 22-12-2015
HGNC name CDC20 cell division cycle 20 homolog (S. cerevisiae)
HGNC id 1723
Location 1p34.2      Physical location : 43.824.625 - 43.828.871
Synonym name cell division cycle 20
Synonym symbol(s) CDC55, p55CDC, MGC102824, bA276H19.3, CDC20A, APC/C(Cdc20)
TYPE functioning gene
STRUCTURE 4.25 kb     11 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Map cen - D9S175 - D9S167 - D9S1812 - CDC20 /D9S1680 - D9S257 - qter
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
11 - 1697 - 499 - 1998 9682218
Type widely
   expressed in (based on citations)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestine   highly
Reproductivefemale systemuteruscervix highly
 female systemovary  highly
SystemCellPubmedSpeciesStageRna symbol
 proliferating cell
cell lineage
cell lines
physiological period embryo
Text highly, in proliferating cells
  • an N-terminal peptide containing AAs 111-150 to bind MAD2L1
  • seven WD40-repeats
  • another MAD2L1-binding domain from AAs 342-355 within the WD repeat region
  • a unique polyhistidine motif with metal binding property adjacent to this second binding domain that may be important for maintaining the overall conformation of CDC20 for its binding to MAD2L1
  • CDC20/fizzy domain
  • two previously described motifs, the C box and the isoleucine-arginine (IR) tail, which are needed for CDC20 to bind to the APC/C as a coactivator
  • the KILR motif was necessary for CDC20 to bind to the APC/C when the spindle assembly checkpoint (SAC) was active
  • mono polymer heteromer , complex
    interspecies homolog to yeast S.cerevisiae CDC20p
    homolog to murine Cdc20 (94.6pc)
  • WD repeat CDC20/Fizzy family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
    text enriched at the centrosome in neurons
    basic FUNCTION
  • involved in ubiquitin mediated proteolysis
  • mediating the association of the mitotic spindle checkpoint protein MAD1L1 with the cyclosome/anaphase-promoting complex (ANAPC/C)
  • required for microtubule dependant nuclear movement prior to anaphase and chromosomes sepration
  • is an essential ANPC/C activator
  • is involved in dendrite morphogenesis in postmitotic neurons
  • CDC20-ANPC regulates presynaptic differentiation in primary postmitotic mammalian neurons
  • activator of the anaphase promoting complex/cyclosome (APC/C) ubiquitin ligase, initiates the destruction of key mitotic regulators to facilitate mitosis, while it is negatively regulated by the spindle assembly checkpoint (SAC) to prevent premature anaphase entry
  • its transcriptional regulatory function was observed to be cell cycle-specific
  • orders passage through the meiotic divisions by ensuring a balance of phosphatases
  • co-activator of the anaphase-promoting complex/cyclosome (APC/C complex), which recruits substrates at particular phases of the cell cycle and mediates their degradation
  • is involved the degradation of SP100 and this process requires the D-box module
  • MAD2L1 competes directly for CDC20 with the anaphase-promoting complex/cyclosome (APC/C), which would contribute to the rapid and potent inhibition of CDC20
  • MAD2L1 is one of the key components of the spindle and mitotic checkpoint complex that regulates the fidelity of cell division along with MAD1L1, CDC20, BUB1B
  • CELLULAR PROCESS cell cycle, division, mitosis
    protein, ubiquitin dependent proteolysis
    a component
  • forming a complex with BUB1B
  • CDC20-ANAPC regulates presynaptic differentiation in primary postmitotic mammalian neurons
    small molecule
  • activating the anaphase promoting complex (APC/C)
  • SPATC1
  • interacting with HDAC6 that stimulates activity of CDC20-ANPC and drives the differentiation of neurons
  • NEUROD2 might be a target of CDC20-ANPC in the control of presynaptic development
  • interaction between HSF2 and the APC/C subunit CDC27 and coactivator CDC20 is enhanced by moderate heat stress, and the degradation of HSF2 is induced during the acute phase of the heat shock response
  • specifically targets E2F1 for degradation in early mitosis and reveal a novel mechanism for limiting free E2F1 levels in cells, failure of which may compromise cell survival and/or homeostasis
  • transcriptionally up-regulates UBE2C expression through its WD40 domain
  • BUB1B-dependent CDC20 proteasomal degradation in G0 phase is required for ciliogenesis
  • FBXW52 is a substrate of both PLK4 and CDC20, two established regulators of centriole duplication
  • binds to key mitotic substrates, targeting them for ubiquitin modification by the APC/C, ultimately resulting in their degradation
  • stable interaction of CDC20 with MAD2 is required to maintain spindle assembly checkpoint (SAC) signaling
  • PHF8 is regulated by CDC20 and plays an important role in the G2/M transition
  • switch from activation of the anaphase-promoting complex/cyclosome (APC/C) by CDC20 to CDH1 during anaphase is crucial for accurate mitosis
  • CHEK1 is required for the metaphase-anaphase transition via regulating the subcellular localization and the expression of CDC20 and MAD2L1
  • FBXO43 inhibits APC/C-CDC20, and functions as a cytostatic factor that causes long-term M phase arrest of mature oocytes
  • cell & other
    inhibited by FBXO5
    RASSF1 (RASSF1 inhibits APC/C(Cdc20) function through its D-box motifs)
    repressed by TP53 (TP53 inhibits tumor cell growth through the indirect regulation of CDC20)
    Other is ubiquitinated by APC/C and degraded to maintain mitotic arrest
    polyubiquitinated by HDAC6
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral       gain of function
    in many types of malignancies and remarkably suppressed by ectopic introduction of TP53
    tumoral     --over  
    of CDC20 and MAD2L1 is related to poor prognosis of urothelial bladder cancer
    Variant & Polymorphism
    Candidate gene
    Therapy target
    might be a good potential therapeutic target for a broad spectrum of human cancer