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FLASH GENE
Symbol CAPNS1 contributors: mct/npt - updated : 01-04-2008
HGNC name calpain, small subunit 1
HGNC id 1481
PROTEIN
PHYSICAL PROPERTIES Hydrophobic
STRUCTURE
motifs/domains
  • a N terminal regulatory domain processed after activation (i)
  • a cysteine protease domain (II)
  • a linker domain (III)
  • four calcium binding domains with calmodulin-like EF hand motifs (IV)
  • two nuclear localization signals (NLS)
  • a gly-rich hydrophobic domain
    • mono polymer heteromer , dimer
    HOMOLOGY
    interspecies homolog to murine Capns1
    Homologene
    FAMILY
  • papain superfamily, nCL-1 type
    • CATEGORY enzyme , regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    text translocated to the plasma membrane upon Ca2+ binding
    basic FUNCTION
  • calcium dependent intracellular neutral cysteine proteinase (non lysosomal)
  • required to maintain stability and activity of both calpains
    • CELLULAR PROCESS cell life, proliferation/growth
    protein, degradation
    PHYSIOLOGICAL PROCESS nervous system
    text
  • neurodegenerative processes implication
  • positive control of cell proliferation
    • PATHWAY
    metabolism
    signaling
    a component
  • heterodimerazing with CAPN1, CAPN2
    • INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Ca2+
    • protein
  • first protease to be identified and validated as a transcriptional target of NRF1
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to myotonic dystrophy and neurodegenerative processes
    Variant & Polymorphism SNP
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    Capn4 knockout mice (Arthur,2000)