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FLASH GENE
Symbol ENTPD6 contributors: - updated : 16-09-2006
HGNC name ectonucleoside triphosphate diphosphohydrolase 6 (putative function)
HGNC id 3368
Location 20p11.2-p11.22      Physical location : 25.176.338 - 25.207.360
Synonym name
  • interleukin 6 signal transducer-2
  • CD39-like 2, homolog to the lymphoid cell activation antigen CD39, and to E type ecto ATpase
    • Synonym symbol(s) IL6ST2, CD39L2, IL-6SAG
    EC.number 3.6.1.5
    DNA
    TYPE functioning gene
    STRUCTURE 31.00 kb     15 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status provisional
    Map cen - THBD - D20S184 - D20S871 - ENTPD6 - D20S863 - cen
    Authors Chadwick (98),LDB (99)
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   predominantly
    Digestiveintestinelarge intestinecolon highly
    Endocrineneuroendocrinepituitary  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text brain
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • one transmembrane segment at the N terminus
  • four apyrase conserved regions (ACR) in the N terminal region
    • conjugated GlycoP
    HOMOLOGY
    intraspecies homolog to 1 lymphoid cell activation antigen CD39
    Homologene
    FAMILY GDA1/CD39 ntpase family
    CATEGORY enzyme , antigen
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    text one recruted form
    basic FUNCTION
  • might support glycosylation reactions in the Golgi apparatus and, when released from cells, might catalyze the hydrolysis of extracellular nucleotides
  • cation-dependent enzyme that hydrolyzing ATP and ADP and also other di- and triphosphate nucleosides, acting at an optimum pH of 8.0
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism purine/pyrimidine
    signaling
    extracellular nucleotides
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • calcium Ca2+
  • magnesium Mg2+
    • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS