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FLASH GENE
Symbol ENTPD6 contributors: - updated : 16-09-2006
HGNC name ectonucleoside triphosphate diphosphohydrolase 6 (putative function)
HGNC id 3368
Location 20p11.2-p11.22      Physical location : 25.176.338 - 25.207.360
Synonym name
  • interleukin 6 signal transducer-2
  • CD39-like 2, homolog to the lymphoid cell activation antigen CD39, and to E type ecto ATpase
  • Synonym symbol(s) IL6ST2, CD39L2, IL-6SAG
    EC.number 3.6.1.5
    DNA
    TYPE functioning gene
    STRUCTURE 31.00 kb     15 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status provisional
    Map cen - THBD - D20S184 - D20S871 - ENTPD6 - D20S863 - cen
    Authors Chadwick (98),LDB (99)
    Physical map
    CST3 20p11.22-p11.21 cystatin C (amyloid angiopathy and cerebral hemorrhage) CST4 20p11.2 cystatin S CST1 20p11.2 cystatin SN CSTP2 20p11.2 cystatin pseudogene 2 CST2 20p11.2 cystatin SA CST5 20p11.21 cystatin D CSTP1 20p11.2 cystatin pseudogene 1 GGTLA4 20p11.1 gamma-glutamyltransferase-like activity 4 LOC284796 20p11.21 similar to hypothetical protein DKFZp434P211.1 - human (fragments) C20orf39 20p11.21 chromosome 20 open reading frame 39 LOC391238 20 LOC391238 CST7 20p11.22-p11.21 cystatin F (leukocystatin) C20orf3 20p11.22-p11.21 chromosome 20 open reading frame 3 ACAS2L 20p11.23-p11.21 acetyl-Coenzyme A synthetase 2 (AMP forming)-like VSX1 20p11.23-p11.22 visual system homeobox 1 homolog, CHX10-like (zebrafish) LOC391239 20 similar to immune costimulatory protein B7-H4 LOC391240 20 similar to nodulin ENTPD6 20q11.2 ectonucleoside triphosphate diphosphohydrolase 6 (putative function) PYGB 20p11.2 phosphorylase, glycogen; brain C20orf22 20 chromosome 20 open reading frame 22 PPIAP2 20 peptidylprolyl isomerase A (cyclophilin A) pseudogene 2 KIAA0186 20pter-cen peptidylprolyl isomerase A (cyclophilin A) pseudogene 2 KIAA0980 20p11.2-p11.1 peptidylprolyl isomerase A (cyclophilin A) pseudogene 2 C20orf147 20p11.1 chromosome 20 open reading frame 147 ZNF337 20p11.1 zinc finger protein 337 C20orf189 20 chromosome 20 open reading frame 189 FLJ38374 20p11.21 hypothetical protein FLJ38374 LOC149934 20p11.21 similar to bB329D4.2.1 (novel protein similar to a truncated nuclear receptor co-repressor 1 (NCOR1) (retinoid X receptor interacting protein 13), isoform 1)
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   predominantly
    Digestiveintestinelarge intestinecolon highly
    Endocrineneuroendocrinepituitary  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text brain
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • one transmembrane segment at the N terminus
  • four apyrase conserved regions (ACR) in the N terminal region
  • conjugated GlycoP
    HOMOLOGY
    intraspecies homolog to 1 lymphoid cell activation antigen CD39
    Homologene
    FAMILY GDA1/CD39 ntpase family
    CATEGORY enzyme , antigen
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    text one recruted form
    basic FUNCTION
  • might support glycosylation reactions in the Golgi apparatus and, when released from cells, might catalyze the hydrolysis of extracellular nucleotides
  • cation-dependent enzyme that hydrolyzing ATP and ADP and also other di- and triphosphate nucleosides, acting at an optimum pH of 8.0
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism purine/pyrimidine
    signaling
    extracellular nucleotides
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • calcium Ca2+
  • magnesium Mg2+
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS