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FLASH GENE
Symbol ETFA contributors: npt/ - updated : 24-07-2006
HGNC name electron-transfer-flavoprotein, alpha polypeptide
HGNC id 3481
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • the N-terminus blocked
    • conjugated FlavoP
    mono polymer heteromer , dimer
    HOMOLOGY
    interspecies ortholog to murine Etfa
    homolog to zebrafish etfa
    ortholog to rattus etfa
    Homologene
    FAMILY
  • ETF alpha-subunit/fixB family
    • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,matrix
    basic FUNCTION
  • participating in catalyzing the initial step of the mitochondrial fatty acid beta-oxidation
  • shuttling electrons between primary flavoprotein dehydrogenases and the membrane-bound electron transfer flavoprotein ubiquinone oxidoreductase
  • serving as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase
  • transferring the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS electron transport
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    fatty acid beta-oxidation
    a component
  • heterodimer of an alpha and a beta subunit, containing one FAD and one AMP molecule per heterodimer
    • INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • FAD (one molecule per dimer)
  • AMP (one molecule per dimer)
    • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) ETFA
    related resource MITOP database
    Susceptibility
    Variant & Polymorphism SNP the unstable variant T171I overreprinted in ACADVL deficient patients with mild childhood presentation
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS