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FLASH GENE
Symbol DUSP9 contributors: mct - updated : 07-03-2007
HGNC name dual specificity phosphatase 9
HGNC id 3076
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver    
Reproductivefemale systemplacenta   
Skin/Tegumentskin    
Urinarykidney    
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo, pregnancy
Text only in placenta, kidney and embryonic liver
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two N terminal CH2 domains
  • an extended active site sequence motif conserved in dual specificity phosphatases
  • a rhodanese domain
  • a tyrosine-protein phosphatase domain
    • HOMOLOGY
    Homologene
    FAMILY dual specificity protein phosphatase subfamily
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • inactivating target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in insulin-sensitive tissues during their differentiation
    Susceptibility
    Variant & Polymorphism
    Candidate gene candidate for the regulation of the stress responses involved in insulin resistance
    Marker
    Therapy target may provide a therapeutic target for treatment of type 2 diabetes
    ANIMAL & CELL MODELS