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FLASH GENE
Symbol METTL1 contributors: mct/npt - updated : 05-11-2019
HGNC name methyltransferase-like 1
HGNC id 7030
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a conserved S-adenosylmethionine-binding motif (Alexandrov 2002)
    • HOMOLOGY
    interspecies ortholog to yeast S. cerevisiae YDL201w
    ortholog to murine Mettl1
    homolog to Drosophila EG:22E5.4
    homolog to C.elegans W02B12.10
    ortholog to yeast Trm8
    Homologene
    FAMILY
  • methyltransferase superfamily
  • TrmB family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • methyltransferase activity
  • required for tRNA 7-methylguanosine-methyltransferase activity (Alexandrov 2002)
  • catalyses the 7-methylguanosine modification of tRNA (Cartlidge 2005)
  • NSUN2 and METTL1, are required for protecting tRNA against tRNA decay (RTD)
  • METTL1 promotes cell proliferation and migration in hepatocellular carcinoma (HCC, and exerts oncogenic activities via suppression of PTEN signaling
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • form a complex with WDR4 (Alexandrov 2002)
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    Other inactivated by AKT1 and RPS6KA1 (Cartlidge 2005)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral       gain of function
    in hepatocellular carcinoma (HCC) and exhibits oncogenic activities via PTEN/AKT1 signaling pathway
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • serves as a promising prognostic biomarker in hepatocellular carcinoma (HCC)
    • Therapy target
    SystemTypeDisorderPubmed
    cancerdigestiveliver
    METTL1/PTEN axis may provide therapeutic potential in HCC intervention
    ANIMAL & CELL MODELS