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FLASH GENE
Symbol CPD contributors: - updated : 09-07-2007
HGNC name carboxypeptidase D
HGNC id 2301
RNA
TRANSCRIPTS type messenger
text several transcripts
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - 8025 180 1380 - O malley
- - - 160 - selectively expressed in several haematopoietic tumour cells O malley
  • has an incomplete N-terminal domain I but intact domains II and III
  • nuclear localization
  • EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Endocrinepancreas    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    Muscularstriatumskeletal  
    cell lineage
    cell lines hepatoma cells
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • B type membrane bound metallocarboxypeptidase comprising
  • three tandem active site domains, three CP domains
  • zinc peptide domain
  • conjugated MetalloP
    isoforms Precursor
    HOMOLOGY
    interspecies ortholog to duck gp180 (hepatitis virus-binding protein)
    ortholog to murine Cpd
    Homologene
    FAMILY zinc carboxypeptidase family, peptidase M14 family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,Golgi
    text localizd in the TGN (trans-Golgi network)
    basic FUNCTION carboxypeptidase, involved in secretory pathway
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    binds 2 zinc ions per subunit
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS