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FLASH GENE
Symbol TAF7 contributors: mct - updated : 30-06-2013
HGNC name TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDa
HGNC id 11541
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY transcription factor
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,Golgi
intracellular,nucleus
basic FUNCTION
  • JUN co-activator mediating activation of AP-1 target genes in response to extracellular signals
  • functions not only as one of the TAFs, but also a coactivator for JUN
  • physiological function of TAF7 as a basal regulator for mammalian polyamine transport activity and polyamine analog MGBG-induced apoptosis
  • role in regulating transcription initiation
  • functions as a check-point regulator suppressing premature transcription initiation until preinitiation complex assembly is complete
  • plays a critical role in regulating TFIID-dependent transcription initiation by preventing premature transcription initiation
  • contributes to the regulation of the transition from preinitiation complex assembly to initiation and elongation
  • regulates transcription initiation of TAF1-dependent genes by binding to the acetyltransferase (AT) domain of TAF1 and inhibiting the enzymatic activity that is essential for transcription
  • role of TAF7 extending beyond canonical TFIID-dependent transcription because it also plays a critical role in regulating CIITA-dependent transcription
  • is likely essential for proliferation but not for proliferation-independent differentiation
  • novel roles for the TAF1-TAF7 complex in regulation of PIC assembly via reading epigenetic histone marks
  • TAF1 and TAF7, two subunits of TFIID, are integral to the regulation of eukaryotic transcription initiation and play key roles in preinitiation complex (PIC) assembly
    • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • TFIID component
    • INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • TATA box binding (TBP)
  • interacts with TAFII230, the largest subunit of TFIID, and with multiple transcription activators, including Sp1,YY1, USF, CTF
  • binds to TAF1 and inhibits its intrinsic acetyl transferase activity
  • interacts with JUN through two independent interaction domains, within the N- and C-terminal part of JUN
  • interacts with the transcription factors, GT2H4 and CDK9
  • binds to CIITA and inhibits its AT (acetyltransferase) activity, thereby repressing activated transcription
  • interacts with and regulates the enzymatic activities of other transcription factors, including CDK9, GTF2H1, and CIITA, ensuring an orderly progression in transcription initiation
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS