Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Orphanet	Ensembl
	HGNC	UniGene	Nucleotide	OMIM		UCSC

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FLASH GENE

Symbol

FHL2

contributors: mct/pgu - updated : 04-10-2023

HGNC name	four and a half LIM domains 2
HGNC id	3703

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

CMD1H

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   in rhabdomyosarcoma constitutional       loss of function leads to impaired assembly of extracellular matrix proteins on the cell surface and to impaired bundling of focal adhesions tumoral       gain of function in colorectal cancer (CRC) compared with matched normal tissues

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer digestive colon FOXK1 and FHL2 may serve as putative targets in the combined therapy of colorectal cancer

ANIMAL & CELL MODELS

up-regulation of Fhl2 may contribute to the antihypertrophic phenotype that is observed in cardiac-specific Rock2-deficient mice