protein
| coactivator of androgen receptor |
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interacting with the DNA replication regulatory protein CDC47 (MCM7) |
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interacting with MAPK2 through two LIM domains |
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inhibited the ability of activated ERK2 to reside within the nucleus, thus blocking ERK-dependent transcriptional responsiveness of ELK-1, GATA4, and the atrial natriuretic factor promoter) |
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binding with NP220 |
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interacting with hydrophilic loop of PSEN2 |
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interacting and corepressing ZNF145 |
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bound to two distinct sites on titin |
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interacting with CCND1 (critical for cyclin D1 activation and cell growth, regulate the activity of the cyclin D1 promoter through its implication in acetylation of transcription factors and histones) |
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interacting with ZNF638, E4F1 and all members of the Id faily (Id1-4) |
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potential KCNH2 partner (interacts with and regulates the KCNH2 channel) |
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FHL1, FHL2, and FHL3 physically and functionally interact with SMAD2, SMAD3, and SMAD4, important regulators of cancer development and progression, in a TGF-beta-independent manner |
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repressor of ID2 |
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FOXK1 interacting protein (FHL2, in a dose-dependent fashion, promotes FOXK1 transcriptional repression of FOXO4 activity) |
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FHL2 is a novel regulator of CCL19-induced dendritic cell (DC) migration |
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represses NR4A1 transcriptional activity in a dose-dependent manner |
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directly interacts with HIF1A to repress transcriptional activity |
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FHL2 controls the osteogenic differentiation of mesenchymal stromal cells (MSC), bone formation and bone mass through modulation of WNT molecules, WNT10B, WNT3A, WNT5A |
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binds and synergistically cooperates with RNF111 to activate SMAD3/SMAD4-dependent transcription |
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is important regulator of RNF111 ubiquitination and TGFB signal transduction |
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FHL2 enhanced TRAF6 activity in transcriptional activation of NFKB1 targets by stabilizing the protein |
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TRAF6 is a binding partner of FHL2 and an important component of the Toll-like receptor-NFKB1 pathway |
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is transcriptionally regulated by diverse types of transcription factors, for example, TP53, serum response factor (SRF), and specificity protein 1 (Sp1) |
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exhibits specific interaction with proteins exhibiting diverse functions, including transmembrane receptors, transcription factors and transcription co-regulators, enzymes, and structural proteins |
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is a critical regulator of TGFB1 expression |
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FHL2, via modulating CTNNB1 signalling, may implicate in regulation of TGFB1-mediated tubular epithelial-to-mesenchymal transition (EMT) |
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FHL2 decreases the inflammatory response of vascular smooth muscle cells (vSMCs) through inhibition of the NFKB1-signalling pathway |
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CMYA5 is a novel FHL2 interaction partner in cardiac myocytes |
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direct interaction of the two adaptor proteins FHL2 and CMYA5 in cardiac myocytes, which might impact subcellular compartmentation of CMYA5 |