| basic FUNCTION
| signaling cell-cell adhesion protein |
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mediating filtration through the podocyte filter which sits at the interface of the capillary and the nephron |
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playing a role in the development or function of the kidney glomerular filtration barrier |
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may anchor the podocyte slit diaphragm to the actin cytoskeleton |
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cooperates with KIRREL to transduce a signal that induces actin polymerization  |
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plays a role in organizing the surface expression of ion channel proteins in podocytes and may play a role in outside-in signaling to allow podocytes to adapt to mechanical or neurohumoral stimuli originating in neighboring cells |
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playing a role in vesicular docking and insulin responsiveness of podocytes |
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may be playing a role in secondary fusion of myoblasts into nascent myotubes |
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transduces a phosphotyrosine signal through its cytoplasmic domain, which contains several putative tyrosine phosphorylation sites for Src-family kinases such as FYN |
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with KIRREL2 could interact homophilically and heterophilically, suggesting that NPHS1 and KIRREL2 might regulate certain developmental aspects of PTF1A-positive neurons as homo- or heterooligomers |
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nephrin and KIRREL are essential components of the slit diaphragm |
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nephrin and KIRREL or KIRREL2 trans-interactions promote cell-contact formation, suggesting that they may also function together in slit diaphragm assembly |
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KIRREL and NPHS1 organize a signaling complex at the podocyte cell membrane that forms the structural framework for a functional glomerular filtration barrier |
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not only has a function in kidney podocytes, but is also required for cardiovascular development |
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serves a crucial function in cardiac vessel development |
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NPHS1 and NGFR share a partial overlapping expression pattern in the epicardium and subepicardial coronary vessels |
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not only initiates actin polymerization but also assembles a protein complex that is necessary to regulate the architecture of the generated actin filament network and focal adhesion dynamics |
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key component of the kidney slit diaphragm that contributes to the morphology of podocyte foot processes through signaling to the underlying actin cytoskeleton |
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dynamic molecular link between nephrin signaling and the canonical Hippo pathway in podocytes, which may facilitate the conversion of mechanical cues to biochemical signals promoting podocyte viability |
