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FLASH GENE

Symbol

MAPK8

contributors: shn - updated : 03-07-2018

HGNC name	mitogen-activated protein kinase 8
HGNC id	6881

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional       gain of function in obesity constitutional       loss of function deficiency in the nervous system is sufficient to account for the role of MAPK8 in the regulation of high-fat diet-induced weight gain

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target	JNK-related therapeutic strategies for RP1 diseases
	System Type Disorder Pubmed diabete     a potential new therapy for diabetes using cell-permeable JNK-inhibitory peptide miscelleaneous vascular   therapeutic target in abdominal aortic aneurysm

ANIMAL & CELL MODELS

	JNK activity observed in wild-type activated TH cells was severely reduced in TH cells from Jnk1-/- mice
	MAPK8 deficient mice display a progressive loss of axonal and dendritic microtubules and MAP1B and MAP2 are hypophosphorylated in MAPK8–/– brains compromising their ability to bind to microtubules and promote their assembly and stability
	Mice lacking both of the ubiquitously expressed isoforms JNK1 and -2 die during midgestation with neural tube closure defects and brain abnormalities
	JNK-deficient mice exhibit delayed epithelial development in the epidermis, intestines, lungs, an eyelid closure defect associated with markedly reduced epidermal growth factor (EGF) receptor function, and loss of expression of the ligand EGF
	genetic loss of the MAPK, c-Jun N-terminal kinase 1 in a mouse model of multiple sclerosis, enhances IL-10 production, rendering innate myeloid cells unresponsive to certain microbes and less capable of generating IL-17-roducing, encephalitogenic T cells