Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Orphanet Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol MYO15A contributors: mct - updated : 12-04-2023
HGNC name myosin XVA
HGNC id 7594
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • very long terminal extension with a high proline content preceding the motor domain comprising one consensus ATP binding site and two putative actin-binding sites
  • a neck containing two IQ calmodulin or calmodulin-like chain binding domains and
  • a tail containing two myosin IV-like,and two C terminal talin-like (FERM) (EPB41,ezrin,radixin,moesin) domains, involved in the linkage of cytoplasmic proteins to the membrane
  • a putative SH3 domain
    • conjugated FlavoP
    mono polymer heteromer
    HOMOLOGY
    Homologene
    FAMILY
  • myosin family
    • CATEGORY motor/contractile
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytoskeleton,intermed filament
    text linked to the plasma membrane
    basic FUNCTION
  • involved in structure and function of auditory and vestibular hair cells
  • playing a necessary role for actin organization in the hair cells of the cochlea
  • may be having a role in secretory granule movement and/or hormone secretion
  • motor protein, necessary for the development of hair cell stereocilia, which are actin-filled projections on the apical surface and the site of mechanotransduction of sound
  • may be involved in cytoplasmic organelle movement, including secretory granules in pituitary cells and pituitary adenomas
  • traffics and delivers critical molecules required for stereocilia development and thus is essential for building the mechanosensory hair bundle
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling sensory transduction/hearing
    a component
  • MYO15A, DFNB31, and EPS8 are integral components of the stereocilia tip complex, where EPS8 is a central actin-regulatory element for elongation of the stereocilia actin core
  • MYO15A-EPS8 complex transports BAIAP2L2 to stereocilia tips, and Ca2+ entry through open channels at row 2 tips retains BAIAP2L2 there
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • BAIAP2L2 localization to stereocilia tips is dependent on the motor protein MYO15A and its cargo EPS8
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) DFNB3
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    overexpressed in endocrine tumors cells
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS