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FLASH GENE
Symbol PLP2 contributors: mct - updated : 23-05-2016
HGNC name proteolipid protein 2 (colonic epithelium-enriched)
HGNC id 9087
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • four transmembrane segments (4TM)
  • a MARVEL domain
    • conjugated GlycoP , LipoP
    mono polymer homomer , polymer
    HOMOLOGY
    interspecies homolog to rattus Plp2 (84.1 pc)
    homolog to murine Plp2 (80.1 pc)
    Homologene
    FAMILY
  • integral membrane protein (proteolipids) family
    • CATEGORY transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    text integral membrane protein
    basic FUNCTION
  • play a role in cell differentiation in the epithelium
  • acting as an ion transmembrane transporter
  • critical function to PLP2 for viral ligase activity
    • CELLULAR PROCESS cell life, differentiation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
  • chemotaxis
  • cytokine and chemokine mediated signaling pathway
    • a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PLP2 (multimerize)
  • chemokine
  • physically interacting with CCT
  • CCR1
  • PLP2 binds specifically to PI3K, thus activating AKT1, and aids metastasis
  • PLP2 and RAB5C are novel TPD52 binding partners
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    directly promotes resistance to ER stressors
    Susceptibility to X-linked mental retardation (XLMR)
    Variant & Polymorphism SNP PLP2-(-113C>A) is sufficient to cause reduced expression and is enriched in a cohort of males with probable XLMR
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Plp2-deficient mice show increased neuronal death to ER stress and hypoxia in vitro and in a neonatal hypoxia-ischemia model