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FLASH GENE
Symbol HCRTR2 contributors: SGE - updated : 23-07-2010
HGNC name hypocretin (orexin) receptor 2
HGNC id 4849
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • seven transmembrane segments (7TM) receptor
    • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to murine Hcrtr2 (94.6pc)
    homolog to rattus Hcrtr2 (94.6pc)
    Homologene
    FAMILY
  • G protein coupled receptor 1 family
    • CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • receptor involved in the regulation of feeding behavior
  • neuropeptide receptor activity
  • hypocretin system modulates neuroendocrine functions and is involved in narcolepsy (Rainero 2004)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding both HCRT isoforms A and B (orexin A and orexin B)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism SNP
  • 1246G->A polymorphism is associated with cluster headache (Rainero 2004)
  • this polymorphism may interfere with the dimerization process of the receptor, thereby influencing its functional activity (Rainero 2008)
    • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS