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FLASH GENE
Symbol HCRTR2 contributors: SGE - updated : 23-07-2010
HGNC name hypocretin (orexin) receptor 2
HGNC id 4849
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineneuroendocrinepituitary   
cell lineage
cell lines somatotrope and corticotrope cells (Blanco 2001)
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • seven transmembrane segments (7TM) receptor
    • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to murine Hcrtr2 (94.6pc)
    homolog to rattus Hcrtr2 (94.6pc)
    Homologene
    FAMILY
  • G protein coupled receptor 1 family
    • CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • receptor involved in the regulation of feeding behavior
  • neuropeptide receptor activity
  • hypocretin system modulates neuroendocrine functions and is involved in narcolepsy (Rainero 2004)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding both HCRT isoforms A and B (orexin A and orexin B)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism SNP
  • 1246G->A polymorphism is associated with cluster headache (Rainero 2004)
  • this polymorphism may interfere with the dimerization process of the receptor, thereby influencing its functional activity (Rainero 2008)
    • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS