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FLASH GENE

Symbol

HCRTR2

contributors: SGE - updated : 23-07-2010

HGNC name	hypocretin (orexin) receptor 2
HGNC id	4849

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

text	four alternative transcripts arising from alternative splicing (Chen 2010)

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001526 7 - 1834 NP_001517 - 444 - Sakurai (1998)

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Endocrine neuroendocrine pituitary

cell lineage
cell lines	somatotrope and corticotrope cells (Blanco 2001)
fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

seven transmembrane segments (7TM) receptor

conjugated

GlycoP

HOMOLOGY

interspecies	homolog to murine Hcrtr2 (94.6pc)
	homolog to rattus Hcrtr2 (94.6pc)

Homologene

FAMILY

G protein coupled receptor 1 family

CATEGORY

receptor membrane G

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION	receptor involved in the regulation of feeding behavior
	neuropeptide receptor activity
	hypocretin system modulates neuroendocrine functions and is involved in narcolepsy (Rainero 2004)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

binding both HCRT isoforms A and B (orexin A and orexin B)

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism SNP	1246G->A polymorphism is associated with cluster headache (Rainero 2004)
	this polymorphism may interfere with the dimerization process of the receptor, thereby influencing its functional activity (Rainero 2008)

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS