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FLASH GENE

Symbol

KCNS2

contributors: npt/ - updated : 17-08-2007

HGNC name	potassium voltage-gated channel, delayed-rectifier, subfamily S, member 2
HGNC id	6301

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	3.77 kb     2 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

Map	cen - D8S1122 - D8S1960 - D8S1625 - KCNV1 - KCNS2 - D8S130 - D8S1482 - D8S1470 - D8S65 - D8S1202 - D8S49 - D8S588 - D8S1204 - D8S539 - D8S1139 - D8S555 - D8S1142 - D8S281 - D8S42 - D8S50 - D8S565 - D8S547 - D8S1200 - D8S51 - D8S1201 - D8S1216 - qter
Authors	Hilton (01)

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed KCNS2 2 - 3219 54 477 - Salinas (1997)

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain forebrain cerebral cortex       brain diencephalon hypothalamus       brain hindbrain cerebellum       spinal cord         Olfactory olfactory bulb

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial         Nervous central

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	six putative membrane-spanning domains
	an hydrophobic pore including the P domain with the K+ channel signature
	TM domains 5 and 6, sensitive to changes in membrane potential
	a putative phosphorylation sites

HOMOLOGY

Homologene

FAMILY	potassium channel family
	subfamily Shab

CATEGORY

transport channel

SUBCELLULAR LOCALIZATION

basic FUNCTION	modulator of Kv2.1,Kv2.2 of Kv2.1 (KCNB1), KU2.2 (KCNB2)
	potassium voltage-gated channel delayed-rectifier

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS