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FLASH GENE

Symbol

HSF4

contributors: mct - updated : 17-04-2010

HGNC name	heat shock transcription factor 4
HGNC id	5227

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

CTM

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional       loss of function leads to defect in lens epithelial cell (LEC) differentiation and cataract formation

Susceptibility

to age related cataract

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed neurosensorial     HSF4-vimentin axis appears to be a new target for developing anti-cataract drugs, especially for those cataracts resulting from aberrations in HSF4 expression

ANIMAL & CELL MODELS

sf4 knockout mouse (Hsf4-/-) partially mimics the human cataract caused by HSF4 mutations