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FLASH GENE

Symbol

CDH17

contributors: - updated : 02-03-2007

HGNC name	cadherin 17, LI cadherin (liver-intestine)
HGNC id	1756

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	8q22.1      Physical location : 95.139.393 - 95.229.531
Synonym name	liver-intestine cadherin
Synonym symbol(s)	HPT1, CDH16, FLJ26931, HPT-1, MGC138218

DNA

TYPE	functioning gene
STRUCTURE	81.00 kb     18 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

regionally located

. located in a region deleted (LOH) in adult acute leukemia

RNA

TRANSCRIPTS	type	messenger

EXPRESSION

Type	restricted

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine small intestine         intestine large intestine colon       liver         Nervous nerve cranial nerve

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a N terminal hydrophobic domain
	five extracellular cadherin repeats with four cysteines in the most proximal
	a transmembrane segment and a highly conserved cytoplasmic tail required for interactions

conjugated

GlycoP

HOMOLOGY

Homologene

FAMILY

cadherin superfamily of calcium dependent cell-cell adhesion glycoproteins

CATEGORY

adhesion

SUBCELLULAR LOCALIZATION

plasma membrane,junction,tight

basic FUNCTION

transmembrane glycoprotein component of adherens junctioninvolved in cell-cell or cell-ECM interactions

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule	metal binding,
	calcium Ca2+

protein	hemophilic,calcium dependent interactions
	interacting by itsC terminus with the cytoskeleton via beta-catenin

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   in colorectal carcinoma with a high tumor grade, lymphatic invasion, lymph node metastasis tumoral     --over   in liver cancer

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS