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FLASH GENE
Symbol CDH13 contributors: mct - updated : 15-02-2019
HGNC name cadherin 13, H-cadherin (heart)
HGNC id 1753
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminal hydrophobic domain
  • five extracellular cadherin repeats with four cysteines in the most proximal (MPED)
  • a transmembrane segment and a highly conserved cytoplasmic tail required for interactions
  • lacks transmembrane and cytoplasmic domains and is anchored to the cell membrane via a glycosylphosphoinositol moiety
    • conjugated GlycoP
    mono polymer dimer
    HOMOLOGY
    interspecies homolog to murine Cdh13
    intraspecies homolog to CDH2
    Homologene
    FAMILY
  • cadherin superfamily of calcium dependent cell-cell adhesion glycoproteins
    • CATEGORY adhesion
    SUBCELLULAR LOCALIZATION     plasma membrane,junction,tight
    plasma membrane,junction,adherens
        intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,nuclear envelope
    text
  • specifically expressed in Golgi cells within the cerebellar cortex
    • basic FUNCTION
  • mediating putatively cell-cell interaction in the heart
  • may act as a negative regulator of neural cell growth
  • playing an important role in cell recognition and adhesion
  • may modulate cell-matrix adhesion in basal keratinocytes as well as invasive potency in cutaneous squamous carcinoma by regulating surface level of beta1 integrin (ITGB1)
  • may have a role in hormone and drug-induced changes in bone morphology and pathology
  • may play an important role in controlling tissue cellularity during vascular remodeling
  • protects endothelial cells from oxidative stress-induced apoptosis
  • negative regulator for gallbladder cancer invasion
  • adhesive capacity is necessary to regulate neurite iutgrowth from CDH13-expressing neurons
  • is a novel component of insulin granules, suggesting that CDH13 contributes to the regulation of insulin secretion independently of direct interactions with ADIPOQ
  • CDH13 expression modulates signalling and functional responses of endothelial cells (EC) to insulin
  • translocation to cell-cell contacts is sensitive to the activity status of EGFR, requires lipid raft domain integrity and actin filament polymerization, and crucial intracellular signalling mediators include RAC1 and MAPK14
  • role for CDH13 in limb revascularization and it is essential for mediating the vascular actions of adiponectin
  • role of CDH13 in regulation of endothelial permeability and its possible engagement in endothelial dysfunction
  • CDH13, GRM8, ANK2, SLC16A6, ARSG, RIMBP2 and DCLK1 having role in hearing function
  • is involved in axonal pathway formation in the developing cortex
  • is a negative regulator of inhibitory synapses in the hippocampus
  • novel protective role for CDH13 in cortical neuron development
  • is a novel positive regulator of autophagy and survival in smooth muscle cells (SMCs)
  • is critical for inhibitory function of Golgi cells
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • forms dimer through an alternative nonswapped interface near the EC1-EC2 calcium binding sites
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding by its C terminus to the cytoskeleton via beta-catenin (hemophilic, calcium dependent interactions)
  • ADIPOQ accumulates in the vasculature via CDH13, and the ADIPOQ-CDH13 association plays a protective role against neointimal and atherosclerotic plaque formations
  • ADIPOQ, an adipocyte-derived circulating protein, accumulates in the heart, vascular endothelium, and skeletal muscles through an interaction with CDH13, a unique glycosylphosphatidylinositol-anchored cadherin
  • is an adiponectin receptor
    • cell & other
  • cell-cell interactions
  • cell-extracellular matrix interactions
    • REGULATION
    Other estradiol, progesterone, EGF, dexamethasone and factors are involved in transcriptional and post-transcriptional regulation of CDH13 in osteosarcoma cells
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   deletion    
    in lung carcinoma
    tumoral     --low  
    hypermethylated or deleted in ovarian, breast, lung and in colorectal cancer and adenoma
    tumoral     --low  
    in diffuse large B cell lymphomas (B-DLCLs) by promoter hyper-methylation
    tumoral     --low  
    by promoter hypermethylation is a common, early event in esophageal adenocarcinogenesis and correlates with clinical risk factors
    tumoral     --low  
    in cutaneous squamous cell carcinoma
    Susceptibility
  • to Attention-deficit/hyperactivity disorder, ADHD
  • to type 2 diabetes (T2DM)
    • Variant & Polymorphism SNP
  • association between the SNP-rs12596316 genotype and T2DM
    • Candidate gene detection of methylation of the gene in blood might have utility in monitoring and detecting tumor recurrence in early-stage non-small cell lung cancer after curative surgical resection
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • mice lacking Cdh13 exhibit reduced cognitive flexibility and loss of preference for contact region concomitant with increased reciprocal social interactions