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FLASH GENE

Symbol

CDH13

contributors: mct - updated : 15-02-2019

HGNC name	cadherin 13, H-cadherin (heart)
HGNC id	1753

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001257 14 polyA site 3842 NP_001248 78.3 713 - 2010 20039275 also called variant 1, isoform 1 NM_001220488 15 - 4134 NP_001207417 - 760 - 2010 20039275 NM_001220489 13 - 3911 NP_001207418 - 674 - 2010 20039275 NM_001220490 13 - 3819 NP_001207419 - 459 - 2010 20039275 NM_001220492 6 - 1006 NP_001207421 - 175 - 2010 20039275 NM_001220491 5 - 955 NP_001207420 - 190 - 2010 20039275

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain hindbrain cerebellum cerebellar cortex   Homo sapiens

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial barrier lining epidermis     Homo sapiens

cells

System Cell Pubmed Species Stage Rna symbol Skin/Tegument keratinocyte Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a N terminal hydrophobic domain
	five extracellular cadherin repeats with four cysteines in the most proximal (MPED)
	a transmembrane segment and a highly conserved cytoplasmic tail required for interactions
	lacks transmembrane and cytoplasmic domains and is anchored to the cell membrane via a glycosylphosphoinositol moiety

conjugated

GlycoP

mono polymer

dimer

HOMOLOGY

interspecies

homolog to murine Cdh13

intraspecies

homolog to CDH2

Homologene

FAMILY

cadherin superfamily of calcium dependent cell-cell adhesion glycoproteins

CATEGORY

adhesion

SUBCELLULAR LOCALIZATION	plasma membrane,junction,tight
	plasma membrane,junction,adherens
	intracellular
	intracellular,cytoplasm,organelle,Golgi
	intracellular,nuclear envelope
text	specifically expressed in Golgi cells within the cerebellar cortex

basic FUNCTION	mediating putatively cell-cell interaction in the heart
	may act as a negative regulator of neural cell growth
	playing an important role in cell recognition and adhesion
	may modulate cell-matrix adhesion in basal keratinocytes as well as invasive potency in cutaneous squamous carcinoma by regulating surface level of beta1 integrin (ITGB1)
	may have a role in hormone and drug-induced changes in bone morphology and pathology
	may play an important role in controlling tissue cellularity during vascular remodeling
	protects endothelial cells from oxidative stress-induced apoptosis
	negative regulator for gallbladder cancer invasion
	adhesive capacity is necessary to regulate neurite iutgrowth from CDH13-expressing neurons
	is a novel component of insulin granules, suggesting that CDH13 contributes to the regulation of insulin secretion independently of direct interactions with ADIPOQ
	CDH13 expression modulates signalling and functional responses of endothelial cells (EC) to insulin
	translocation to cell-cell contacts is sensitive to the activity status of EGFR, requires lipid raft domain integrity and actin filament polymerization, and crucial intracellular signalling mediators include RAC1 and MAPK14
	role for CDH13 in limb revascularization and it is essential for mediating the vascular actions of adiponectin
	role of CDH13 in regulation of endothelial permeability and its possible engagement in endothelial dysfunction
	CDH13, GRM8, ANK2, SLC16A6, ARSG, RIMBP2 and DCLK1 having role in hearing function
	is involved in axonal pathway formation in the developing cortex
	is a negative regulator of inhibitory synapses in the hippocampus
	novel protective role for CDH13 in cortical neuron development
	is a novel positive regulator of autophagy and survival in smooth muscle cells (SMCs)
	is critical for inhibitory function of Golgi cells

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

forms dimer through an alternative nonswapped interface near the EC1-EC2 calcium binding sites

INTERACTION

DNA

RNA

small molecule

protein	binding by its C terminus to the cytoskeleton via beta-catenin (hemophilic, calcium dependent interactions)
	ADIPOQ accumulates in the vasculature via CDH13, and the ADIPOQ-CDH13 association plays a protective role against neointimal and atherosclerotic plaque formations
	ADIPOQ, an adipocyte-derived circulating protein, accumulates in the heart, vascular endothelium, and skeletal muscles through an interaction with CDH13, a unique glycosylphosphatidylinositol-anchored cadherin
	is an adiponectin receptor

cell & other	cell-cell interactions
	cell-extracellular matrix interactions

REGULATION

Other

estradiol, progesterone, EGF, dexamethasone and factors are involved in transcriptional and post-transcriptional regulation of CDH13 in osteosarcoma cells

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral   deletion     in lung carcinoma tumoral     --low   hypermethylated or deleted in ovarian, breast, lung and in colorectal cancer and adenoma tumoral     --low   in diffuse large B cell lymphomas (B-DLCLs) by promoter hyper-methylation tumoral     --low   by promoter hypermethylation is a common, early event in esophageal adenocarcinogenesis and correlates with clinical risk factors tumoral     --low   in cutaneous squamous cell carcinoma

Susceptibility

to Attention-deficit/hyperactivity disorder, ADHD to type 2 diabetes (T2DM)

Variant & Polymorphism SNP	association between the SNP-rs12596316 genotype and T2DM

Candidate gene	detection of methylation of the gene in blood might have utility in monitoring and detecting tumor recurrence in early-stage non-small cell lung cancer after curative surgical resection
Marker
Therapy target

ANIMAL & CELL MODELS

mice lacking Cdh13 exhibit reduced cognitive flexibility and loss of preference for contact region concomitant with increased reciprocal social interactions