Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

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FLASH GENE

Symbol

CDH11

contributors: mct - updated : 27-08-2015

HGNC name	cadherin 11, type 2, OB-cadherin (osteoblast)
HGNC id	1750

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral   LOH     in retinoblastoma tumoral     --low   in breast cancer, correlated with a loss of the epithelial phenotype and with a gain of invasiveness constitutional     --other   down-modulation by potent antiinflammatory therapies in humans with arthritis may contribute to halting cartilage damage ( tumoral     --over   expression increasing from primary to metastatic disease in lymph nodes and especially bone

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed immunology autoimmune articular useful therapeutic target for inflammatory arthritis

ANIMAL & CELL MODELS

cadherin-11-deficient mice have a hypoplastic synovial lining, display a disorganized synovial reaction to inflammation, and are resistant to inflammatory arthritis