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FLASH GENE

Symbol

CDH11

contributors: mct - updated : 27-08-2015

HGNC name	cadherin 11, type 2, OB-cadherin (osteoblast)
HGNC id	1750

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Hearing/Equilibrium ear       highly Lymphoid/Immune spleen       highly Respiratory respiratory tract larynx     highly   respiratory tract trachea     highly

cells

System Cell Pubmed Species Stage Rna symbol   chondrocyte

cell lineage	osteoblasts
cell lines
fluid/secretion

at STAGE

physiological period

embryo

Text	expressed through early development and strongly during inner ear development (otic placode and vesicle)

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a N terminal hydrophobic domain
	five extracellular cadherin repeats with four cysteines in the most proximal (MPED)
	a transmembrane segment and a highly conserved cytoplasmic tail required for interactions

conjugated

GlycoP

HOMOLOGY

Homologene

FAMILY

cadherin superfamily of calcium dependent cell-cell adhesion glycoproteins

CATEGORY

adhesion

SUBCELLULAR LOCALIZATION	plasma membrane,junction,tight
	intracellular
	intracellular,cytoplasm
text	integral membrane protein

basic FUNCTION	transmembrane glycoprotein component of adherens junction, invoved in cell-cell or cell-ECM interactions
	playing a key role in the specific adhesion of fibroblast-like synoviocytes and in synovial tissue organization
	potentially involved in the metastasis of prostate cancer cells to bone
	important in embryogenesis and bone morphogenesis, invasion of cancer cells, lymphangiogenesis, homing of cancer cells to bone, and rheumatoid arthritis
	involved in the controls of otolith assembly (
	dispensable for postnatal skeletal growth, but it favors osteogenesis over adipogenesis
	CDH2 and CDH11 are crucial regulators of postnatal skeletal growth and bone mass maintenance, serving overlapping, yet distinct, functions in the osteogenic lineage
	modulates synovial fibroblasts to evoke inflammatory factors that may contribute to the inflammatory process in rheumatoid arthritis (RA)
	directly modulates cytokine production by synovial fibroblasts, particularly IL6
	is a functional tumor suppressor and an important antagonist of Wnt/CTNNB1 and AKT1/RHOA signaling, with frequent epigenetic inactivation in common carcinomas
	CDH2 and CDH11 act as regulators of stem cell fate decisions

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	hemophilic, calcium dependent interactions
	interacting by its C terminus with the cytoskeleton via beta-catenin
	may be an important modulator of IL6 production by synovial fibroblasts
	PRDM88 is an obligate partner of BHLHE22, forming a repressor complex that directs neural circuit assembly in part through the precise regulation of CDH11

cell & other

REGULATION

Other	mRNA and protein levels are regulated by the activity of GSK3B and a significant degree of this regulation is exerted by the GSK3 target, beta-catenin, at the level of CDH11 3prime UTR

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral   LOH     in retinoblastoma tumoral     --low   in breast cancer, correlated with a loss of the epithelial phenotype and with a gain of invasiveness constitutional     --other   down-modulation by potent antiinflammatory therapies in humans with arthritis may contribute to halting cartilage damage ( tumoral     --over   expression increasing from primary to metastatic disease in lymph nodes and especially bone

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed immunology autoimmune articular useful therapeutic target for inflammatory arthritis

ANIMAL & CELL MODELS

cadherin-11-deficient mice have a hypoplastic synovial lining, display a disorganized synovial reaction to inflammation, and are resistant to inflammatory arthritis