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FLASH GENE
Symbol CDH11 contributors: mct - updated : 27-08-2015
HGNC name cadherin 11, type 2, OB-cadherin (osteoblast)
HGNC id 1750
DNA
TYPE functioning gene
STRUCTURE 175.23 kb     13 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
Map see TSG16H
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
13 - 3654 - 796 - 2002 12438268
conserved cytoplasmic domain
- splicing 3825 - 693 - Murimoto
  • truncated cytoplasmic C-terminal domain
  • promotes invasion of cadherin-11-positive breast cancer cells
    		•
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Hearing/Equilibriumear   highly
    Lymphoid/Immunespleen   highly
    Respiratoryrespiratory tractlarynx  highly
     respiratory tracttrachea  highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
     chondrocyte
    cell lineage osteoblasts
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo
    Text expressed through early development and strongly during inner ear development (otic placode and vesicle)
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N terminal hydrophobic domain
  • five extracellular cadherin repeats with four cysteines in the most proximal (MPED)
  • a transmembrane segment and a highly conserved cytoplasmic tail required for interactions
    • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY cadherin superfamily of calcium dependent cell-cell adhesion glycoproteins
    CATEGORY adhesion
    SUBCELLULAR LOCALIZATION     plasma membrane,junction,tight
        intracellular
    intracellular,cytoplasm
    text integral membrane protein
    basic FUNCTION
  • transmembrane glycoprotein component of adherens junction, invoved in cell-cell or cell-ECM interactions
  • playing a key role in the specific adhesion of fibroblast-like synoviocytes and in synovial tissue organization
  • potentially involved in the metastasis of prostate cancer cells to bone
  • important in embryogenesis and bone morphogenesis, invasion of cancer cells, lymphangiogenesis, homing of cancer cells to bone, and rheumatoid arthritis
  • involved in the controls of otolith assembly (
  • dispensable for postnatal skeletal growth, but it favors osteogenesis over adipogenesis
  • CDH2 and CDH11 are crucial regulators of postnatal skeletal growth and bone mass maintenance, serving overlapping, yet distinct, functions in the osteogenic lineage
  • modulates synovial fibroblasts to evoke inflammatory factors that may contribute to the inflammatory process in rheumatoid arthritis (RA)
  • directly modulates cytokine production by synovial fibroblasts, particularly IL6
  • is a functional tumor suppressor and an important antagonist of Wnt/CTNNB1 and AKT1/RHOA signaling, with frequent epigenetic inactivation in common carcinomas
  • CDH2 and CDH11 act as regulators of stem cell fate decisions
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • hemophilic, calcium dependent interactions
  • interacting by its C terminus with the cytoskeleton via beta-catenin
  • may be an important modulator of IL6 production by synovial fibroblasts
  • PRDM88 is an obligate partner of BHLHE22, forming a repressor complex that directs neural circuit assembly in part through the precise regulation of CDH11
    • cell & other
    REGULATION
    Other mRNA and protein levels are regulated by the activity of GSK3B and a significant degree of this regulation is exerted by the GSK3 target, beta-catenin, at the level of CDH11 3prime UTR
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   LOH    
    in retinoblastoma
    tumoral     --low  
    in breast cancer, correlated with a loss of the epithelial phenotype and with a gain of invasiveness
    constitutional     --other  
    down-modulation by potent antiinflammatory therapies in humans with arthritis may contribute to halting cartilage damage (
    tumoral     --over  
    expression increasing from primary to metastatic disease in lymph nodes and especially bone
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    immunologyautoimmunearticular
    useful therapeutic target for inflammatory arthritis
    ANIMAL & CELL MODELS
    cadherin-11-deficient mice have a hypoplastic synovial lining, display a disorganized synovial reaction to inflammation, and are resistant to inflammatory arthritis