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FLASH GENE
Symbol PALM contributors: mct - updated : 16-05-2011
HGNC name paralemmin
HGNC id 8594
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • to the inner side of plasma membrane through a C terminal, prenylpalmitoyl anchor
    • conjugated LipoP , PhosphoP
    HOMOLOGY
    interspecies ortholog to murine Palm
    Homologene
    FAMILY paralemmin family
    CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic,vesicle
    text
  • localizes to dendritic membranes
    • basic FUNCTION
  • may be involved in control of cell shape
  • implicated as a potent modulator of cellular cAMP signaling within the brain (
  • role in the formation and stabilization of plasma
    • membrane elaborations, in neurons as well as in other cell types
  • regulator of filopodia induction and spine maturation
  • key role in spine maturation through modulation of filopodia induction
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling neurotransmission
    a component constituent of brain synaptic plasma membranes (inner side)
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • specifically interacts with the third intracellular loop of the D3 dopamine receptor
  • interacting with ZDHHC8, ZDHHC3 that modulates paralemmin-1 palmitoylation
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS