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FLASH GENE
Symbol PALM contributors: mct - updated : 16-05-2011
HGNC name paralemmin
HGNC id 8594
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineadrenal glandmedulla  moderately
Nervousbrain   highly Homo sapiens
Reproductivemale systemtestis  highly
Urinarykidney     Homo sapiens
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Nervousautonomous   
Nervousperipherous   
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousneuron
cell lineage
cell lines
fluid/secretion
at STAGE
Text brain
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • to the inner side of plasma membrane through a C terminal, prenylpalmitoyl anchor
    • conjugated LipoP , PhosphoP
    HOMOLOGY
    interspecies ortholog to murine Palm
    Homologene
    FAMILY paralemmin family
    CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic,vesicle
    text
  • localizes to dendritic membranes
    • basic FUNCTION
  • may be involved in control of cell shape
  • implicated as a potent modulator of cellular cAMP signaling within the brain (
  • role in the formation and stabilization of plasma
    • membrane elaborations, in neurons as well as in other cell types
  • regulator of filopodia induction and spine maturation
  • key role in spine maturation through modulation of filopodia induction
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling neurotransmission
    a component constituent of brain synaptic plasma membranes (inner side)
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • specifically interacts with the third intracellular loop of the D3 dopamine receptor
  • interacting with ZDHHC8, ZDHHC3 that modulates paralemmin-1 palmitoylation
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS